component of the SpoIIIAH-SpoIIQ type III secretion system residing in the forespore membrane, required for anchoring of proteins on both sides of the sporulation septum, required for localization and stability of SpoIIE
function
forespore encasement by the spore coat
product
part of the transmembrane channel linking the mother cell and the forespore
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|sporulation proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|SigF regulon]Gene
Coordinates on the chromosome (coding sequence)
3,759,702 -> 3,760,553
The protein
Catalyzed reaction/ biological activity
required for forespore encasement by the spore coat [Pubmed|22171814]required for the recruitment of [SW|SpoIIIAH] to the [SW|sporulation] septum on the mother cell side [Pubmed|23834622]required for the proper localization and stability of [SW|SpoIIE] [Pubmed|26929302]Structure
[PDB|3UZO]; [PDB|3TUF] (the [SW|SpoIIQ]-[SW|SpoIIIAH] pore forming complex) [Pubmed|22431604,22431613][SW|Localization]
membrane protein, forms a transmembrane channel linking the mother cell and the forespore (with [SW|SpoIIIAH]) [Pubmed|22431604,22431613,22171814]septal membranes on the forespore side [Pubmed|27381174]proper [SW|localization] requires [SW|SpoIIIAH], [SW|GerM] and degradation of septal peptidoglycan by the cell wall hydrolases [SW|SpoIID] and [SW|SpoIIP] [Pubmed|23834622][SW|Interactions]
[SW|SpoIIIAH](12)-[SW|SpoIIQ](12) (interaction between proteins membrane proteins expressed in the mother cell and the forespore, respectively; the complex forms a 60 Å channel made up of twelve subunits of each protein) [Pubmed|22431604,22431613,15574594,21097616][SW|SpoIIQ]-[SW|SpoIIE][SW|GerM]-[SW|SpoIIQ] [Pubmed|27381174]Expression and Regulation
Operon
''spoIIQ'' [Pubmed|9140963][SW|Sigma factor]
[protein|search|SigF] [Pubmed|16497325,9140963]Regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325,15699190,9140963]References
Reviews
Original publications
18812514,15752199,18077456,18485064,15574594,15044948,15882622,19609349,9140963,20444098,17121846,18160039,21097616,16497325,15699190,22431613,22171814,23834622,22431604,23859254,25356555,26929302,27381174 
