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mccB [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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mccB [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

cystathionine lyase/ homocysteine gamma-lyase
locus
BSU27250
pI
5.22
mw
40.00 kDa
function
methionine-to-cysteine conversion
product
cystathionine lyase/ homocysteine gamma-lyase
essential
no
ec
4.4.1.1
synonyms
yrhB

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|CymR regulon], [SW|Spx regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,785,001 -> 2,786,140

    The protein

    Catalyzed reaction/ biological activity

  • L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate (according to Swiss-Prot)
  • Protein family

  • trans-sulfuration enzymes family (according to Swiss-Prot)
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|yrrT]-[protein|search|mtnN]-[protein|search|mccA]-[protein|search|mccB]-[protein|search|yrhC]'' [Pubmed|17056751]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|16513748]
  • Regulation

  • repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16513748]
  • Regulatory mechanism

  • [protein|search|CymR]: transcription repression [Pubmed|16513748]
  • [protein|search|Spx]: transcription activation [Pubmed|12642660,16885442]
  • Biological materials

    Mutant

  • 1A942 ( ''mccB''::''kan''), [Pubmed|17056751], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A942&Search=1A942 BGSC]
  • 1A945 ( ''mccB''::''kan''), [Pubmed|17056751], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A945&Search=1A945 BGSC]
  • References

  • 17056751,16513748,16885442,12642660