3-hydroxyacyl-CoA dehydratase
function
fatty acid degradation
product
3-hydroxyacyl-CoA dehydratase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][SW|Categories] containing this gene/protein
[SW|utilization of lipids], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|FadR regulon]Gene
Coordinates on the chromosome (coding sequence)
2,917,166 -> 2,917,942
The protein
Catalyzed reaction/ biological activity
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O (according to Swiss-Prot)Protein family
enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)Modification
phosphorylated on Arg-230 [Pubmed|22517742]Structure
[PDB|3PEA] (from ''B. anthracis'', 49% identity, 66% similarity)Expression and Regulation
Operon
''[protein|search|lcfA]-[protein|search|fadR]-[protein|search|fadB]-[protein|search|etfB]-[protein|search|etfA]'' [Pubmed|17189250]''[protein|search|fadR]-[protein|search|fadB]-[protein|search|etfB]-[protein|search|etfA]'' [Pubmed|17189250][SW|Sigma factor]
''[protein|search|lcfA]'': [protein|search|SigA] [Pubmed|21398533]''[protein|search|fadR]'': [protein|search|SigA] [Pubmed|17189250]Regulation
induced by long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]subject to carbon catabolite repression (3.8-fold) ([protein|search|CcpA]-[PtsH|search|HPr(Ser-P)] [Pubmed|12850135,21398533]Regulatory mechanism
[protein|search|FadR]: transcription repression [Pubmed|17189250][protein|search|CcpA]-[PtsH|search|HPr(Ser-P)]: transcription repression [Pubmed|21398533]Biological materials
Mutant
1A854 ( ''fadB''::''cat''), [Pubmed|17085570], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A854&Search=1A854 BGSC]References
12850135,17189250,17919287,22517742 
