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efp [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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efp [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

elongation factor P, important for the proteins containing three or more consecutive proline residues
locus
BSU24450
pI
4.00
mw
20.00 kDa
function
translation
product
elongation factor P
essential
no
synonyms
yqhU, yqgF

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.11|Translation factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming]
  • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|membrane proteins], [SW|sporulation/ other]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,538,115 -> 2,538,672

    Phenotypes of a mutant

  • impaired swarming motility [Pubmed|15066026,27002156]
  • inactivation of ''[SW|efp]'' reduces sporulation efficiency to 1% that of wild type cells [Pubmed|26735940]
  • The protein

    Protein family

  • transpeptidase family (according to Swiss-Prot) elongation factor P family (according to Swiss-Prot)
  • Modification

  • carries a 5-aminopentanol moiety at Lys-32, this modification is essential for activity [Pubmed|27002156]
  • Structure

  • [PDB|1YBY] (Efp from ''Clostridium thermocellum'')
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot), cell membrane (according to Swiss-Prot)
  • Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]
  • Expression and Regulation

    Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]
  • Biological materials

    Mutant

  • BKE24450 (''[protein|search|efp]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)
  • References

    Reviews

  • 26416626
  • Original publications

  • 15066026,17981983,23239624,23239623,25310979,25144653,27002156,26735940,27216360,26384033