SubtiBank SubtiBank
ntdA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
SAVE THE DATE! 21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.

ntdA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase
locus
BSU10550
pI
5.97
mw
49.00 kDa
function
synthesis of the antibiotic kanosamine
product
pyridoxal phosphate-dependent
essential
no
synonyms
yhjL

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]
  • [SW|Categories] containing this gene/protein

  • [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]
  • This gene is a member of the following [SW|regulons]

  • [SW|NtdR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,128,286 -> 1,129,611

    The protein

    Catalyzed reaction/ biological activity

  • 3-oxo-d-glucose-6-phosphate + glutamate --> kanosamine-6-phosphate [Pubmed|23586652]
  • Protein family

  • degT/dnrJ/eryC1 family (according to Swiss-Prot)
  • [SW|Cofactors]

  • pyridoxalphosphate [Pubmed|23586652]
  • Structure

  • [PDB|4K2I] [Pubmed|24097983]
  • [SW|Interactions]

  • forms dimers [Pubmed|24097983]
  • Expression and Regulation

    Operon

  • ''[protein|search|ntdA]-[protein|search|ntdB]-[protein|search|ntdC]-[protein|search|glcP]'' [Pubmed|17056753]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|14612444]
  • Regulation

  • induced by 3,3'-neotrehalosadiamine ([protein|search|NtdR]) [Pubmed|14612444]
  • Regulatory mechanism

  • [protein|search|NtdR]: positive regulator [Pubmed|14612444]
  • References

    Reviews

  • 21512256
  • Original publications

  • 19087206,19342798,17056753,14612444,23586652,24097983