ntdA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase

locus: BSU10550

pI: 5.97

mw: 49.00 kDa

function: synthesis of the antibiotic kanosamine

product: pyridoxal phosphate-dependent

essential: no

synonyms: yhjL

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]

[SW|Categories] containing this gene/protein

• [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]

This gene is a member of the following [SW|regulons]

• [SW|NtdR regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,128,286 -> 1,129,611

The protein

Catalyzed reaction/ biological activity

• 3-oxo-d-glucose-6-phosphate + glutamate --> kanosamine-6-phosphate [Pubmed|23586652]

Protein family

• degT/dnrJ/eryC1 family (according to Swiss-Prot)

[SW|Cofactors]

• pyridoxalphosphate [Pubmed|23586652]

Structure

• [PDB|4K2I] [Pubmed|24097983]

[SW|Interactions]

• forms dimers [Pubmed|24097983]

Expression and Regulation

Operon

• ''[protein|search|ntdA]-[protein|search|ntdB]-[protein|search|ntdC]-[protein|search|glcP]'' [Pubmed|17056753]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|14612444]

Regulation

• induced by 3,3'-neotrehalosadiamine ([protein|search|NtdR]) [Pubmed|14612444]

Regulatory mechanism

• [protein|search|NtdR]: positive regulator [Pubmed|14612444]

References

Reviews

• 21512256

Original publications

• 19087206,19342798,17056753,14612444,23586652,24097983