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trmU [Mon Jan 18 2016 18:07:55 GMT+0100 (CET)]
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trmU [Mon Jan 18 2016 18:07:55 GMT+0100 (CET)]

tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase, involved in 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules
locus
BSU27500
pI
4.00
mw
42.00 kDa
function
tRNA modification
product
tRNA (5-methylaminomethyl-2-thiouridylate) methyltransferase
essential
yes
synonyms
yrrA, mnmA

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,809,413 -> 2,810,528

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • 2-thiouridine (s2U) modification of the wobble position in glutamate, glutamine and lysine tRNA molecules (together with [protein|search|YrvO]) [Pubmed|25825430]
  • Protein family

  • mnmA/TRMU family (according to Swiss-Prot)
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • [SW|Interactions]

  • [protein|search|YrvO]-[protein|search|TrmU] [Pubmed|25825430]
  • Expression and Regulation

    Operon

  • ''[protein|search|cymR]-[protein|search|yrvO]-[protein|search|trmU]'' [Pubmed|16885442]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|16885442]
  • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • References

  • 16885442,11948165,25825430