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hrcA [Tue Dec 06 2016 16:21:34 GMT+0100 (CET)]
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hrcA [Tue Dec 06 2016 16:21:34 GMT+0100 (CET)]

transcriptional repressor of class I heat-shock genes
locus
BSU25490
pI
6.00
mw
38.00 kDa
function
regulation of chaperone gene expression
product
transcriptional repressor
essential
no
synonyms
yqxE, yqeS
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

    • [SW|Categories] containing this gene/protein

  • [SW|transcription factors and their control], [SW|heat shock proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|HrcA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,628,606 -> 2,629,637

    The protein

    Catalyzed reaction/ biological activity

  • transcription repressor of the ''[protein|search|hrcA]-[protein|search|grpE]-[protein|search|dnaK]-[protein|search|dnaJ]-[protein|search|yqeT]-[protein|search|yqeU]-[protein|search|yqeV]'' and ''[SW|groES]-[SW|groEL]'' operons (at low/ normal temperatures)

    • Protein family

  • hrcA family (according to Swiss-Prot)

    • Modification

  • phosphorylated on arginine residues [Pubmed|24263382]

    • [SW|Cofactors]

  • [SW|GroEL] acts as co-repressor

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • [SW|Interactions]

  • [SW|GroEL]-[protein|search|HrcA]

    • Expression and Regulation

    Operon

  • ''[protein|search|hrcA]-[protein|search|grpE]-[protein|search|dnaK]-[protein|search|dnaJ]-[protein|search|yqeT]-[protein|search|yqeU]-[protein|search|yqeV]'' [Pubmed|9023197]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1339421]

    • Regulation

  • induced by heat shock ([protein|search|HrcA]) [Pubmed|1339421]

    • Regulatory mechanism

  • [protein|search|HrcA]: transcription repression [Pubmed|1339421]

    • Labs working on this gene/protein

  • [SW|Wolfgang Schumann], Bayreuth University, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/schumann_research.htm Homepage]
  • [SW|Thomas Wiegert], University of Bayreuth, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/Thomas Wiegert-Dateien/Thomas Wiegert.html Homepage]

    • References

    Reviews

  • 27518094

    • Original Publications

  • 8113175,9023197,9303302,10383760,8576042,12799007,11717291,12082092,1339421,7540247,1339421,9303302,7592421,24263382