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pgsA [Tue Nov 08 2016 10:32:18 GMT+0100 (CET)]
phosphatidylglycerophosphate synthase
function
biosynthesis of phospholipids
product
phosphatidylglycerophosphate synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|biosynthesis of lipids], [SW|essential genes], [SW|membrane proteins]Gene
Coordinates on the chromosome (coding sequence)
1,762,623 -> 1,763,204
Phenotypes of a mutant
some point mutations resulting in reduced PgsA activity lead to daptomycin resistance [Pubmed|21709092]essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
CDP-diacylglycerol sn-glycerol 3-phosphate = CMP 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (according to Swiss-Prot) Protein family
CDP-alcohol phosphatidyltransferase class-I family (according to Swiss-Prot)[SW|Localization]
cell membrane at the septum [Pubmed|19820159,15743965]Biological materials
Mutant
1A815 ( ''pgsA''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A815&Search=1A815 BGSC]References
19745567,16514141,19820159,15743965,21709092 
