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21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.
biosynthesis of phospholipids
categories[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 188.8.131.52|Biosynthesis of phospholipids][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
Phenotypes of a mutantsome point mutations resulting in reduced PgsA activity lead to daptomycin resistance [Pubmed|21709092]essential [Pubmed|12682299]depletion leads to hypersensitivity to sorbic acid stress [Pubmed|27818647]
Catalyzed reaction/ biological activityCDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate --> 1,2-diacyl-sn-glycero-3-phospho-(1ʼ-sn-glycero-3ʼ-phosphate) + CMP + H+ (according to UniProt)
Protein familyCDP-alcohol phosphatidyltransferase class-I family (with [protein|DE49797486CEC172F912D26A6BF2223190BF5DAD|PssA], according to UniProt)
[SW|Localization]cell membrane at the septum [Pubmed|19820159,15743965]
Mutant1A815 ( ''pgsA''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A815&Search=1A815 BGSC]