radC [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

probable DNA repair protein

locus: BSU28040

pI: 7.00

mw: 25.00 kDa

function: DNA repair

product: probable DNA repair protein

essential: no

synonyms: ysxA

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination], [SW|genetic competence], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|phosphoproteins]

This gene is a member of the following [SW|regulons]

• [SW|ComK regulon], [SW|SigM regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,861,840 -> 2,862,535

The protein

Protein family

• radC family (according to Swiss-Prot)

Modification

• phosphorylated on Arg-59 [Pubmed|22517742]

[SW|Localization]

• cytoplasm (Homogeneous) [Pubmed|16479537]

Expression and Regulation

Operon

• ''[protein|search|maf]-[protein|search|radC]-[protein|search|mreB]-[protein|search|mreC]-[protein|search|mreD]-[protein|search|minC]-[protein|search|minD]'' [Pubmed|22383849]

[SW|Sigma factor]

• promoter p1 (upstream of ''[protein|search|maf]''): [SW|SigA] [Pubmed|26091431]
• promoter p2 (within ''[protein|search|maf]''): [SW|SigM] [Pubmed|18179421]]

Regulation

• expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]
• expression is increased in an ''[protein|search|ugtP]'' mutant [Pubmed|22362028]

Regulatory mechanism

• expressed in response to cell wall antibiotics, ethanol, heat, acid, and superoxide stress ([protein|search|SigM]) [Pubmed|12775685]
• expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]
• [protein|search|ComK]: transcription activation [Pubmed|11948146,11918817]

References

• 17434969,11948146,11918817,16479537,12775685,18179421,22517742,24009114,21926231,22383849,26091431