yloI

Coenzyme A biosynthesis bifunctional protein CoaBC; putative phosphopantothenoylcysteine synthetase/decarboxylase

Locus: BSU_15700

Isoelectric point: 6.01

Molecular weight: 43.82 kDa

Protein length: 406 aa

Gene length: 1221 bp

Function: biosynthesis of coenzyme A

Product: putative phosphopantothenoylcysteine synthetase/decarboxylase

Essential: yes

E.C.: 4.1.1.36

Synonyms: coaBC

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of coenzyme A
• Groups of genes → Essential genes

Gene

Coordinates: 1,642,851 1,644,071

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• H⁺ + N-[(R)-4-phosphopantothenoyl]-L-cysteine --> CO₂ + D-pantetheine 4'-phosphate (according to UniProt)
• (R)-4'-phosphopantothenate + CTP + L-cysteine --> CMP + diphosphate + H⁺ + N-[(R)-4-phosphopantothenoyl]-L-cysteine (according to UniProt)

Protein family

• N-terminal part: HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily (single member, according to UniProt)
• C-terminal part: PPC synthetase family (single member, according to UniProt)

Structure

• 1U7U (from E. coli, 41% identity in 53% fragment) PubMed

Expression and Regulation

Operons

• Genes: yloC-remA-gmk-yloH-yloI-priA-defA-fmt-yloM-yloN

  Description

  • PubMed

Biological materials

Mutant

• MGNA-B372 (yloI::erm), available at the NBRP B. subtilis, Japan

References

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