product
aspartyl-tRNA synthetase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes], [SW|phosphoproteins], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Coordinates on the chromosome (coding sequence)
2,814,743 -> 2,816,521
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP L-aspartate tRNA(Asp) = AMP diphosphate L-aspartyl-tRNA(Asp) (according to Swiss-Prot) Protein family
class-II aminoacyl-tRNA synthetase family (according to Swiss-Prot)Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705]Structure
[PDB|1EQR] (from ''Escherichia coli'', 52% identity, 68% similarity) [Pubmed|10873442]Expression and Regulation
Operon
''[protein|search|hisS]-[protein|search|aspS]Regulation
induced by histidine or aspartate limitation ([protein|search|T-box]) [Pubmed|19258532]Regulatory mechanism
[protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
19258532,15378759,16493705,26804570 
