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txpA [Sat Jan 28 2017 12:56:38 GMT+0100 (CET)]
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txpA [Sat Jan 28 2017 12:56:38 GMT+0100 (CET)]

toxic peptide, eliminates defective cells from developing biofilms
locus
BSU26050
pI
8.00
mw
6.00 kDa
function
toxin
product
toxic peptide
essential
no
synonyms
yqcR

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.1|Type 1 TA systems]
  • [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.3|Skin element]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|toxins, antitoxins and immunity against toxins], [SW|Skin element], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|ratA regulon], [SW|Spo0A regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,678,240 -> 2,678,419

    The protein

    Catalyzed reaction/ biological activity

  • part of a type I toxin/antitoxin system (with [SW|RatA]) [Pubmed|27450630]
  • eliminates defective cells from developing biofilms [Pubmed|27450630]
  • [SW|Localization]

  • cell membrane
  • Expression and Regulation

    Operon

  • ''txpA'' [Pubmed|16166525]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|16166525]
  • Regulation

  • induced by amino acid limitation [Pubmed|27450630]
  • Regulatory mechanism

  • [SW|Spo0A]: transcription activation [Pubmed|27450630]
  • expression is prevented by the ''[protein|search|ratA]'' antisense RNA [Pubmed|16166525]
  • the ''[protein|search|txpA]'' mRNA-''[protein|search|RatA]'' RNA duplex is degraded by [rnc|search|RNase III] [Pubmed|23300471]
  • Additional information

  • next to '[protein|search|yonT]', the '[protein|search|txpA]' mRNA has the strongest Shine-Dalgarno region in 'B. subtilis' [PubMed|19210617]
  • Labs working on this gene/protein

  • [SW|Richard Losick], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ Homepage]
  • References

    Reviews

  • 23300472
  • Original publications

  • 16166525,19210617,23300471,27450630