NAD-dependent glucose-6-phosphate dehydrogenase
function
synthesis of the antibiotic kanosamine
product
NAD-dependent glucose-6-phosphate dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]This gene is a member of the following [SW|regulons]
[SW|NtdR regulon]Gene
Coordinates on the chromosome (coding sequence)
1,126,400 -> 1,127,452
The protein
Catalyzed reaction/ biological activity
glucose-6-phosphate + NAD --> 3-oxo-d-glucose-6-phosphate + NADH(2) [Pubmed|23586652]Protein family
gfo/idh/mocA family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YfiI], [protein|search|YrbE], [protein|search|YteT], [protein|search|YulF], [protein|search|IolW], [protein|search|IolX], [protein|search|IolG][SW|Cofactors]
NAD(+) [Pubmed|23586652]Expression and Regulation
Operon
''[protein|search|ntdA]-[protein|search|ntdB]-[protein|search|ntdC]-[protein|search|glcP]'' [Pubmed|17056753][SW|Sigma factor]
[protein|search|SigA] [Pubmed|14612444]Regulation
induced by 3,3'-neotrehalosadiamine ([protein|search|NtdR]) [Pubmed|14612444]Regulatory mechanism
[protein|search|NtdR]: positive regulator [Pubmed|14612444]References
Reviews
Original publications
19087206,17056753,14612444,23586652 
