alkA [Mon Aug 31 2015 13:52:04 GMT+0200 (CEST)]

DNA-3-methyladenine glycosylase

locus: BSU01800

pI: 8.15

mw: 35.00 kDa

function: adaptive response to alkylative DNA damage

product: DNA-3-methyladenine glycosylase

essential: no

ec: 3.2.2.21

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]
• [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.4|Prophage 1]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination], [SW|prophage 1], [SW|sporulation proteins]

This gene is a member of the following [SW|regulons]

• [SW|AdaA regulon]

The protein

Catalyzed reaction/ biological activity

• Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine (according to Swiss-Prot)

Protein family

• alkylbase DNA glycosidase alkA family (according to Swiss-Prot)

Expression and Regulation

Operon

• [protein|search|alkA] [Pubmed|8376346]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8376346]

Regulatory mechanism

• [protein|search|AdaA]: positive regulation [Pubmed|8376346]

References

Reviews

• 22933559,24810496

Original publications

• 8376346