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thrB [Mon Jun 06 2016 13:08:36 GMT+0200 (CEST)]
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thrB [Mon Jun 06 2016 13:08:36 GMT+0200 (CEST)]

homoserine kinase
locus
BSU32240
pI
4.00
mw
33.00 kDa
function
biosynthesis of threonine
product
homoserine kinase
essential
no
ec
2.7.1.39
synonyms
thrA

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]
  • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon], [SW|ThrR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,312,844 -> 3,313,773

    The protein

    Catalyzed reaction/ biological activity

  • ATP L-homoserine = ADP O-phospho-L-homoserine (according to Swiss-Prot)
  • Protein family

  • Homoserine kinase subfamily (according to Swiss-Prot)
  • Structure

  • [PDB|3HUL] (from ''Listeria monocytogenes'', 41% identity, 61% similarity)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|hom]-[protein|search|thrC]-[protein|search|thrB]'' [Pubmed|12107147]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|24163341]
  • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|24163341]
  • [protein|search|ThrR]: transcription repression [Pubmed|27260660]
  • References

  • 12107147,3098560,24163341,27260660