SubtiBank SubtiBank
yabJ [Tue Dec 13 2016 11:16:29 GMT+0100 (CET)]
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yabJ [Tue Dec 13 2016 11:16:29 GMT+0100 (CET)]

required for activity of PurR
locus
BSU00480
pI
5.13
mw
13.00 kDa
function
regulation of purine biosynthesis
product
unknown
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.12|Biosynthesis/ acquisition of branched-chain amino acids]
  • [category|SW 2|Metabolism] → [category|SW 2.7|Detoxification reactions]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|transcription factors and their control]
  • This gene is a member of the following [SW|regulons]

  • [SW|PurR regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    55,295 -> 55,672

    The protein

    Protein family

  • Ref.3 (according to Swiss-Prot) YjgF family
  • Structure

  • [PDB|1QD9], 1QD9 [http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?Dopt=s&uid=11484 NCBI] [Pubmed|10557275]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • [SW|Interactions]

  • forms a trimer [Pubmed|10557275]
  • Expression and Regulation

    Operon

  • ''[protein|search|purR]-[protein|search|yabJ]'' [Pubmed|7638212]
  • Regulation

  • negative autoregulation [Pubmed|7638212]
  • repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]
  • Regulatory mechanism

  • repression by [protein|search|PurR] [Pubmed|7638212]
  • [protein|search|PurR]: transcription repression [Pubmed|7638212]
  • References

  • 10368157,7638212,7638212,10557275