function
late mother cell-specific gene expression
product
RNA polymerase sporulation-specific sigma factor
(sigma-K) (N-terminal half)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][SW|Categories] containing this gene/protein
[SW|transcription], [SW|sigma factors and their control], [SW|sporulation proteins], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|GerE regulon], [SW|SigE regulon], [SW|SigK regulon], [SW|SpoIIID regulon], [SW|ScoC regulon]Gene
Coordinates on the chromosome (coding sequence)
2,652,993 -> 2,653,463
The protein
Protein family
sigma-70 factor family (according to Swiss-Prot)[SW|Interactions]
[SW|SpoIVFB]-pro[protein|search|SigK] [Pubmed|23995631,23585539,19805276][protein|search|SigK]-([protein|search|RpoB]-[protein|search|RpoC])Expression and Regulation
Operon
''[protein|search|sigK]'' (composed of ''[SW|spoIVCB]-[SW|spoIIIC]'') [Pubmed|2536191][SW|Sigma factor]
[protein|search|SigE] [Pubmed|15699190,2841290], [protein|search|SigK] [Pubmed|2841290]Regulation
expressed during sporulation in the mother cell ([protein|search|SigE], [protein|search|SigK], [protein|search|GerE], [SW|SpoIIID]) [Pubmed|15699190,2841290,10075739,7966271]Regulatory mechanism
[protein|search|GerE]: transcription repression [Pubmed|10075739][SW|SpoIIID]: transcription activation [Pubmed|7966271][SW|ScoC]: transcription repression [Pubmed|25983726]Additional information
[protein|search|SigK] is activated by processing of membrane-bound pro-[protein|search|SigK] by the [protein|search|SpoIVFB] metalloprotease [PubMed|23585539,19805276]'spoIVCB' and '[protein|search|spoIIIC]' form a composite gene in the mother cell during sporulation by excising the intervening DNA sequence.Labs working on this gene/protein
[SW|Arthur Aronson], Purdue University, West Lafayette, USA [http://wwwdev.gradschool.purdue.edu/PULSe/faculty.cfm?fid=5&range=0 homepage][SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]References
Reviews
The [SW|SigK regulon]
16385044,15383836,21670523 Original Publications
14526016,17720779,1900494,10438769,2492118,1691789,2536191,2163341,10931284,1577688,9852018,1942049,7814326,8550479,11959848,9501233,10400595,2115401,7592342,1518043,8226681,9078383,2514119,10611287,14523132,19805276,10075739,7966271,17890309,23585539,23995631,25983726 
