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bsrG [Mon Jan 25 2016 11:14:17 GMT+0100 (CET)]
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bsrG [Mon Jan 25 2016 11:14:17 GMT+0100 (CET)]

hydrophobic toxin; interferes with cell envelope biosynthesis, causes membrane invaginations together with delocalization of the cell wall synthesis machinery, triggers autolysis, and inhibits protein biosynthesis
locus
new_2273515_2273748
pI
0.00
mw
0.00 kDa
function
stability of prophage SPß
product
hydrophobic class I toxin
essential
no
synonyms
bsrG,S809

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.1|Type 1 TA systems]
  • [SW|Categories] containing this gene/protein

  • [SW|toxins, antitoxins and immunity against toxins], [SW|SP-beta prophage], [SW|membrane proteins]
  • Gene

    Coordinates on the chromosome
    2,273,515 -> 2,273,748

    Protein

    [SW|Localization]

  • membrane protein (based on the presence of a trans-membrane domain) [Pubmed|22229825]
  • Expression and Regulation

    Operon

  • ''[SW|bsrG]'' [Pubmed|22229825]
  • Sigma factor

  • [SW|SigA] [Pubmed|22229825]
  • Regulation

  • expression increases at the onset of the stationary phase [Pubmed|22229825]
  • the mRNA is destabilized upon interaction with the antitoxin RNA [protein|search|SR4] [Pubmed|22229825]
  • the mRNA is degraded by [protein|search|Rnc], [protein|search|Rny] and [protein|search|Rnr] [Pubmed|22229825]
  • Regulatory mechanism

  • the mRNA is degraded by [protein|search|Rnc], [protein|search|Rny] and [protein|search|Rnr], degradation is enhanced at higher temperature [Pubmed|22229825]
  • at elevated temperatures, [SW|Rny] and [SW|RnjA] are responsible for the enhance degradation of the mRNA [Pubmed|26802042]
  • Additional information

  • half-life of the mRNA: 15 min [Pubmed|22229825]
  • Labs working on this gene/protein

  • [SW|Sabine Brantl], Jena, Germany
  • References

    Original publications

  • 18948176,20525796,23969414,22229825,26234942,26802042