SAVE THE DATE!
21st International Conference on Bacilli and Gram-Positive Bacteria. Prague, Czech Republic, June 7-11, 2021.
hydrophobic toxin; interferes with cell envelope biosynthesis, causes membrane invaginations together with delocalization of the cell wall synthesis machinery, triggers autolysis, and inhibits protein biosynthesis
stability of prophage SPß
hydrophobic class I toxin
categories[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 220.127.116.11|Type 1 TA systems]
2,273,515 → 2,273,748
[SW|Localization]membrane protein (based on the presence of a trans-membrane domain) [Pubmed|22229825]
Expression and Regulation
sigma factors[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|22229825], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
regulationexpression increases at the onset of the stationary phase [pubmed|22229825]the mRNA is destabilized upon interaction with the antitoxin RNA [gene|10A53E2465B5EAA307A099052FBBDF3B62857291|SR4] [pubmed|22229825]
regulatory mechanismthe mRNA is degraded by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III], [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] and [protein|0472A4346ADA1DC41C9D00E8F3222A0EBB76DFA8|RNase R], degradation is enhanced at higher temperature [pubmed|22229825]
Additional informationhalf-life of the mRNA: 15 min [pubmed|22229825]upon heat shock, the mRNA refolds and is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] and [protein|3EB289D0F58A58C693AB588798EE66A731341999|RNase J1][pubmed|22229825]view in new tab
labs[SW|Sabine Brantl], Jena, Germany