SubtiBank SubtiBank
yvaE
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yvaE

similar to multidrug-efflux transporter
locus
BSU_33570
pI
8.13
mw
12.82 kDa
protein length
119 aa Sequence Blast
gene length
360 bp Sequence Blast
function
unknown
product
subunit of unidentified multidrug transporter
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.14|Multidrug exporters]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.14|Resistance against toxins/ antibiotics/ based on similarity]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,448,693 3,449,052

    The protein

    Protein family

  • paired small multidrug resistance protein family ([SW|PSMR family]) [Pubmed|17942072]
  • [SW|drug/metabolite transporter (DMT) superfamily] (according to UniProt)
  • [SW|Small multidrug resistance (SMR) (TC 2.A.7.1) family] (according to UniProt)

    • Structure

  • [PDB|3B5D] (from E. coli, 44% identity) [pubmed|18024586]

    • [SW|Localization]

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|97CE9735931D02E6E780C955C9BE3A67E5C4C59A|yvaF]-[gene|230D790937DAFB82A04B8597699115E1C1EAE98E|yvaE]-[gene|B7FBC30B744D8B1F26AFC5DCB297FAFAB5C60FB7|yvaD]
    description
    [pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-A502 (yvaE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/502 NBRP B. subtilis, Japan]
  • BKE33570 ([gene|230D790937DAFB82A04B8597699115E1C1EAE98E|yvaE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGCCAAGCATAGAAACACCC, downstream forward: _UP4_GTACATAAAAGCGGGCAGTA
  • BKK33570 ([gene|230D790937DAFB82A04B8597699115E1C1EAE98E|yvaE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGCCAAGCATAGAAACACCC, downstream forward: _UP4_GTACATAAAAGCGGGCAGTA

    • References

    Reviews

  • 17942072

    • Original publications

  • 21926231,18024586