branched-chain amino acid transporter, major transporter for isoleucine and valine, may also be involved in threonine transport
function
biosynthesis/acquisition of branched-chain amino acids
product
branched-chain amino acid transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.4|APC superfamily][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.12|Biosynthesis/ acquisition of branched-chain amino acids][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.8|Biosynthesis/ acquisition of serine/ glycine/ alanine][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.8|Utilization of threonine/ glycine][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.9|Utilization of branched-chain amino acids][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|biosynthesis/ acquisition of amino acids], [SW|utilization of amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon]Gene
Coordinates on the chromosome (coding sequence)
1,023,350 -> 1,024,747
Phenotypes of a mutant
no phenotype for the single mutant, the triple ''[protein|search|bcaP] [protein|search|brnQ] [protein|search|braB]'' mutant is strongly impaired in the transport of isoleucine and valine at low concentrations [Pubmed|25645558]resistant to growth inhibition by high concentrations of threonine [Pubmed|25645558]The protein
Catalyzed reaction/ biological activity
high affinity uptake of isoleucine and valine [Pubmed|25645558]Paralogous protein(s)
[protein|search|YfnA][SW|Localization]
cell membrane [Pubmed|18763711]Expression and Regulation
Regulation
repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455,21097623]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|12618455,21097623,18083814,21699902]Biological materials
Mutant
BKE09460 (''[protein|search|bcaP]''::''erm'', available in the BGSC and in [SW|Fabian Commichau]'s and [SW|Jörg Stülke]'s labs)References
18083814,12618455,20935095,18763711,21097623,21699902,25645558,25777134 
