penicillin-binding protein X
product
penicillin-binding protein X
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|penicillin-binding proteins]This gene is a member of the following [SW|regulons]
[SW|SigM regulon], [SW|SigV regulon], [SW|SigX regulon]Gene
Coordinates on the chromosome (coding sequence)
1,765,859 -> 1,767,034
Phenotypes of a mutant
increased sensitivity to lysozyme [Pubmed|21856855]inactivation of ''[protein|search|pbpX]'' strongly restores beta-lactam resistance in a ''[protein|search|sigM]'' mutant [Pubmed|22211522]The protein
[SW|Localization]
extracellular (signal peptide) [Pubmed|18957862]localizes during sporulation to both asymmetric septa and the prespore [http://www.ncbi.nlm.nih.gov/sites/entrez/15758244 Link to a summary]Expression and Regulation
Operon
''pbpX'' [Pubmed|14762009][SW|Sigma factor]
[protein|search|SigM] [Pubmed|18179421], [protein|search|SigX] [Pubmed|14762009,15758244], [protein|search|SigV] [Pubmed|21926231]Regulation
expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]References
14762009,18957862,18179421,21856855,21926231,22211522 
