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srfAC [Mon Aug 31 2015 13:52:25 GMT+0200 (CEST)]
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srfAC [Mon Aug 31 2015 13:52:25 GMT+0200 (CEST)]

surfactin synthetase / competence
locus
BSU03510
pI
4.97
mw
143.00 kDa
function
antibiotic synthesis
product
surfactin synthetase / competence
essential
no
synonyms
comL

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.4|Swarming]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • syns
    comL

    [SW|Categories] containing this gene/protein

  • [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds], [SW|membrane proteins], [SW|phosphoproteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|Abh regulon], [SW|CodY regulon], [SW|ComA regulon], [SW|PerR regulon], [SW|Spx regulon]
  • The protein

    Protein family

  • acyl carrier domain (according to Swiss-Prot)
  • Modification

  • phosphorylation on Ser-1003 [Pubmed|17218307]
  • Structure

  • [PDB|2VSQ]
  • [SW|Localization]

  • cell membrane [Pubmed|18763711]
  • Expression and Regulation

    Operon

  • ''[SW|srfAA]-[SW|srfAB]-[protein|search|comS]-[SW|srfAC]-[SW|srfAD]'' [Pubmed|1715856]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1715856]
  • Regulation

  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8830686]
  • repressed during hydrogen peroxide stress ([protein|search|PerR]) [Pubmed|16166527]
  • expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]
  • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|8830686]
  • [protein|search|ComA]: transcription activation [Pubmed|1715856,16091051]
  • [protein|search|PerR]: transcription activation [Pubmed|16166527]
  • [protein|search|Spx]: transcription repression [Pubmed|12642660]
  • [protein|search|Abh]: transcription repression[Pubmed|20817675]
  • References

    Reviews

  • 20735481