SubtiBank SubtiBank
metC [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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metC [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

cystathionine beta-lyase
locus
BSU11880
pI
5.76
mw
42.00 kDa
function
biosynthesis of methionine
product
cystathionine beta-lyase
essential
no
ec
4.4.1.8
synonyms
yjcJ

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]
  • This gene is a member of the following [SW|regulons]

  • [SW|S-box]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,259,606 -> 1,260,778

    The protein

    Catalyzed reaction/ biological activity

  • L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate (according to Swiss-Prot)
  • Protein family

  • trans-sulfuration enzymes family (according to Swiss-Prot)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|metI]-[protein|search|metC]'' [Pubmed|11832514]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|11832514]
  • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]
  • Regulatory mechanism

  • [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]
  • Biological materials

    Mutant

  • 1A944 ( ''metC''::''kan''), [Pubmed|11832514], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A944&Search=1A944 BGSC]
  • 1A940 ( ''metC''::''spec''), [Pubmed|11832514], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A940&Search=1A940 BGSC]
  • References

  • 19258532,11832514,18039762,12107147