trxB [Fri Feb 26 2016 17:41:24 GMT+0100 (CET)]

thioredoxin reductase (NADPH)

locus: BSU34790

pI: 4.00

mw: 34.00 kDa

function: keeps TrxA|thioredoxin in the reduced state

product: thioredoxin reductase (NADPH)

essential: yes

ec: 1.8.1.9

synonyms: yvcH

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|electron transport/ other], [SW|resistance against oxidative and electrophile stress], [SW|essential genes]

This gene is a member of the following [SW|regulons]

• [SW|Spx regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,573,207 -> 3,574,157

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Thioredoxin NADP = thioredoxin disulfide NADPH (according to Swiss-Prot)

Protein family

• class-II pyridine nucleotide-disulfide oxidoreductase family (according to Swiss-Prot)

[SW|Cofactors]

• FMN or FAD [Pubmed|21635694]

Structure

• [PDB|4GCM] (from ''S. aureus, 71% identity'')

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Regulatory mechanism

• [protein|search|Spx]: transcription activation [Pubmed|12642660]

Additional information

• A [protein|search|ncRNA] is predicted between '[protein|search|yvcI]' and '[protein|search|trxB]' [PubMed|20525796]

References

Reviews

• 23899494

Original publications

• 20084284,12642660,20525796,24401092