mntC

manganese [SW|ABC transporter] (membrane protein)

locus: BSU_30750

pI: 9.35

mw: 47.78 kDa

protein length: 435 aa

gene length: 1308 bp

function: manganese uptake

product: manganese [SW|ABC transporter] (membrane protein)

essential: no

synonyms: ytgC

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.6|Uptake of ions]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 3,142,954 3,144,261

The protein

Protein family

• ABC-3 integral membrane protein family (with [protein|EE212953BC83BD6D69BF769D6E917F4F954BE1E2|ZnuB] and [protein|F7DA077FE47DBB409BE2B1D9F12A9D719C246166|MntD], according to UniProt)

[SW|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|3C40A6E42A669E77ADBF5FFF334061C51F76A4F9|mntA]-[gene|7821C82C6C30079F713B84F1E4D654E07CE5072E|mntB]-[gene|1B7C4AD6CD0632051A0E8CA57034872D13FF67F9|mntC]-[gene|F7DA077FE47DBB409BE2B1D9F12A9D719C246166|mntD]
  description: [Pubmed|10760146]

  regulatory mechanism

  • [protein|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR]: repression, [Pubmed|12950915], in [regulon|FF34DC303E8A7C9FAA205A6C2924961963B14EB1|MntR regulon]

  regulation

  • repressed at high Mn(II) concentrations ([protein|search|MntR]) [Pubmed|12950915]

  additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]

Biological materials

Mutant

• MGNA-A287 (ytgC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/287 NBRP B. subtilis, Japan]
• BKE30750 ([gene|1B7C4AD6CD0632051A0E8CA57034872D13FF67F9|mntC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE30750 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCACAAACTTTCAAACATTG, downstream forward: _UP4_GATGCCGAGAAGGGACAGAT
• BKK30750 ([gene|1B7C4AD6CD0632051A0E8CA57034872D13FF67F9|mntC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK30750 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCACAAACTTTCAAACATTG, downstream forward: _UP4_GATGCCGAGAAGGGACAGAT

labs

• [SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

References

• 10760146,10092453,12950915,10760146,10760146