glycine betaine-aldehyde dehydrogenase, glycine betaine synthesis
product
glycine betaine-aldehyde dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.4|Biosynthesis of glycine betaine][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|coping with hyper-osmotic stress]This gene is a member of the following [SW|regulons]
[SW|GbsR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,185,092 -> 3,186,564
The protein
Catalyzed reaction/ biological activity
Betaine aldehyde NAD H2O = betaine NADH (according to Swiss-Prot)Protein family
aldehyde dehydrogenase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YfmT], [protein|search|AldY], [protein|search|YcbD], [protein|search|GabD], [protein|search|DhaS], [protein|search|IolA], [protein|search|PutC], [protein|search|RocA], [protein|search|AldX], [protein|search|YwdH]Structure
[http://pdb.org/pdb/explore/explore.do?structureId=4QTO 4QTO] (from ''Staphylococcus aureus'', 67% identity, 87% similarity)Expression and Regulation
Operon
'' [protein|search|gbsA]-[protein|search|gbsB]'' [Pubmed|8752328][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8752328]Regulation
induced by choline ([protein|search|GbsR]) [Pubmed|22408163,8752328]Regulatory mechanism
[protein|search|GbsR]: transcription repression [Pubmed|22408163]Biological materials
Mutant
1A1056 ( ''gbsA''::''kan''), [Pubmed|21296969], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A1056&Search=1A1056 BGSC]Labs working on this gene/protein
[SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]References
9297465,8752328,21296969,22408163 
