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purE [Mon Aug 31 2015 13:52:54 GMT+0200 (CEST)]
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purE [Mon Aug 31 2015 13:52:54 GMT+0200 (CEST)]

phosphoribosylaminoimidazole carboxylase (ATP-dependent)
locus
BSU06420
pI
5.20
mw
17.00 kDa
function
purine biosynthesis
product
phosphoribosylaminoimidazole carboxylase (ATP-dependent)
essential
no
ec
4.1.1.21
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides]
  • This gene is a member of the following [SW|regulons]

  • [SW|G-box], [SW|PurR regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 (according to Swiss-Prot)
  • Protein family

  • AIR carboxylase family (according to Swiss-Prot)
  • Structure

  • [PDB|1O4V] (from ''Thermotoga maritima'', 53% identity, 64% similarity) [Pubmed|15048837]
  • Expression and Regulation

    Operon

  • ''[protein|search|purE]-[protein|search|purK]-[protein|search|purB]-[protein|search|purC]-[protein|search|purS]-[protein|search|purQ]-[protein|search|purL]-[protein|search|purF]-[protein|search|purM]-[protein|search|purN]-[protein|search|purH]-[protein|search|purD]'' [Pubmed|3036807]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|3036807]
  • Regulation

  • repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]
  • repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]
  • repressed in the presence of guanine([protein|search|G-box]) [Pubmed|3036807]
  • Regulatory mechanism

  • [PurR]]: transcription repression [Pubmed|7638212]
  • [protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750]
  • [protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [http://www.ncbi.nlm.nih.gov/sites/entrez/3036807 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed2]
  • References

  • 12787499,3036807,12923093,7638212