glsA [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

glutaminase, low affinity for glutamine

locus: BSU02430

pI: 5.32

mw: 36.00 kDa

function: glutamine degradation

product: glutaminase

essential: no

ec: 3.5.1.2

synonyms: ybgJ

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.1|Utilization of glutamine/ glutamate]

[SW|Categories] containing this gene/protein

• [SW|utilization of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|GlnL regulon]

Gene

Coordinates on the chromosome (coding sequence): 264,191 -> 265,174

The protein

Catalyzed reaction/ biological activity

• l-glutamine + H₂O = L-glutamate + NH₃ (according to Swiss-Prot)

Protein family

• glutaminase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YlaM]

Structure

• [PDB|3BRM] [PDB|1MKI][Pubmed|18459799]

Expression and Regulation

Operon

• ''[protein|search|glsA]-[protein|search|glnT]'' [Pubmed|15995196]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|15995196]

Regulation

• induced in the presence of glutamine ([protein|search|GlnL]) [Pubmed|15995196]

Regulatory mechanism

• [protein|search|GlnL]: transcription activation [Pubmed|15995196]

References

• 15995196,18459799