SubtiBank SubtiBank
dapF
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dapF

diaminopimelate epimerase
locus
BSU_32170
pI
4.51
mw
30.72 kDa
protein length
284 aa Sequence Blast
gene length
855 bp Sequence Blast
function
biosynthesis of lysine and peptidoglycan
product
diaminopimelate epimerase
essential
yes
ec
5.1.1.7
synonyms
yutL

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    3,306,040 3,306,894

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • LL-2,6-diaminoheptanedioate --> meso-2,6-diaminopimelate (according to UniProt)
  • Protein family

  • diaminopimelate epimerase family (single member, according to UniProt)
  • Structure

  • [PDB|2OTN] (from ''Bacillus anthracis str. ames'', 62% identity, 75% similarity)
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|185B6596F0468B76BCA85E8753063FAE83445E18|dapF]-[gene|94A3B5EF4ADCFA57A204B584B6D305A62E3E15AE|sufA]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • MGNA-B574 (yutL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1573 NBRP B. subtilis, Japan]