gamma-amino butyric acid permease and minor proline permease
function
utilization of gamma-amino butyric acid
product
gamma-amino butyric acid permease
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.1|Amino acid transporters] → [category|SW 1.2.4.1.4|APC superfamily][category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.4|Transporter for organic acids][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.10|Utilization of gamma-amino butyric acid][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|utilization of amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|TnrA regulon]Gene
Phenotypes of a mutant
defective in the utilization of gamma-amino butyrate [Pubmed|24142252]The protein
Catalyzed reaction/ biological activity
uptake of gamma-amino butyrate [Pubmed|24142252]minor transporter for proline (allows growth with proline in the absence of the major [SW|transporters] [protein|search|PutP] and [protein|search|OpuE]) [Pubmed|24142252]Paralogous protein(s)
[protein|search|AapA], [protein|search|HutM], [protein|search|RocC], [protein|search|RocE], [protein|search|YbgF], [protein|search|YbxG], [protein|search|YdgF], [protein|search|YtnA], [protein|search|YvbW][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''gabP'' [Pubmed|8951816][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8951816]Regulation
expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|8951816]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|8951816]Regulatory mechanism
[protein|search|TnrA]: transcription activation [Pubmed|8951816][protein|search|CodY]: transcription repression [Pubmed|8951816]Biological materials
Mutant
available in [SW|Erhard Bremer]'s lab [Pubmed|24142252]References
8951816,9677314,24142252,25755103 
