fbpB

[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]-regulated basic protein, acts as RNA chaperone for [protein|CE542AE1A32CCD1ABB259E6159F7A37A8078E189|FsrA], response to iron limitation

locus: BSU_04530

pI: 10.73

mw: 6.88 kDa

protein length: 59 aa

gene length: 180 bp

function: RNA chaperone

product: [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]-regulated basic protein, acts as RNA chaperone for [protein|CE542AE1A32CCD1ABB259E6159F7A37A8078E189|FsrA], response to iron limitation

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]
• [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.2|RNA chaperones]
• [category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides]

Gene

Coordinates: 506,322 506,501

Phenotypes of a mutant

• transcription profile of a ''[gene|35ABF185A1AD60E21ECF32AF9D01123307B5152D|fbpA] [gene|147AFEBEA546FDBEEB08E9A8D9C7BCDC9B83CC90|fbpB]'' double mutant strain: [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27416 GEO] [Pubmed|22389480]

Expression and Regulation

Operons

• genes: [gene|35ABF185A1AD60E21ECF32AF9D01123307B5152D|fbpA]-[gene|147AFEBEA546FDBEEB08E9A8D9C7BCDC9B83CC90|fbpB]
  description: [pubmed|18697947]

  regulatory mechanism

  • [protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]

  regulation

  • induced by iron starvation (third wave, under extreme starvation, iron sparing response) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393,12354229]

Biological materials

Mutant

• BKE04530 ([gene|147AFEBEA546FDBEEB08E9A8D9C7BCDC9B83CC90|fbpB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE04530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTTTCTAACTCCGTCAGC, downstream forward: _UP4_TAAAAAGAGCCGGTAAGGCT
• BKK04530 ([gene|147AFEBEA546FDBEEB08E9A8D9C7BCDC9B83CC90|fbpB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK04530 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTTTCTAACTCCGTCAGC, downstream forward: _UP4_TAAAAAGAGCCGGTAAGGCT

References

• 12354229,18697947,20525796,22389480,22427629,29133393