SubtiBank SubtiBank
pcp
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pcp

pyrrolidone-carboxylate peptidase
locus
BSU_02650
pI
6.42
mw
23.63 kDa
protein length
215 aa Sequence Blast
gene length
648 bp Sequence Blast
function
removal of the N-terminal pyroglutamyl group from peptides
product
pyrrolidone-carboxylate peptidase
essential
no
ec
3.4.11.8
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.8|Protein modification/ other]
  • Gene

    Coordinates
    286,773 287,420

    The protein

    Catalyzed reaction/ biological activity

  • Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro (according to Swiss-Prot)
  • Protein family

  • peptidase C15 family (single member, according to UniProt)
  • Structure

  • [PDB|1AUG] (from B. amyloliquefaciens, 72% identity) [pubmed|10196127]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]
    description
    [pubmed|22383849]
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    Biological materials

    Mutant

  • BKE02650 ([gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE02650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTCCCATCTCCTTTTT, downstream forward: _UP4_CACTAAGCGGCCGCCGCTGT
  • BKK02650 ([gene|13E80EAC33C30BB0BBF08A0F0E37EB18CC87C8CA|pcp]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK02650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTCCCATCTCCTTTTT, downstream forward: _UP4_CACTAAGCGGCCGCCGCTGT
  • References

  • 1362573,1353026,10196127