SubtiBank SubtiBank
SR4
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SR4

antitoxin RNA, inhibits [gene|24A1B22DE468F187B6631D3D4E214B64CB8BB4DD|bsrG] translation and causes destabilization of the [gene|24A1B22DE468F187B6631D3D4E214B64CB8BB4DD|bsrG] mRNA
locus
new_2273724_2273988_c
pI
0.00
mw
0.00 kDa
gene length
265 bp Sequence Blast
function
protection of the cell
product
antitoxin RNA
synonyms
SR4,S810
Outlinks

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.1|Type 1 TA systems]
  • [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.5|Regulatory RNAs]
  • Gene

    Coordinates
    2,273,724 → 2,273,988

    Phenotypes of a mutant

  • cell lysis on agar plates [Pubmed|22229825]
  • RNA

    Catalyzed reaction/ biological activity

  • binds the [gene|24A1B22DE468F187B6631D3D4E214B64CB8BB4DD|bsrG] mRNA and triggers its degradation [Pubmed|22229825], moreover SR4 inhibits [gene|24A1B22DE468F187B6631D3D4E214B64CB8BB4DD|bsrG] [SW|translation] [Pubmed|23969414]
  • Expression and Regulation

    Operons

    genes
    [gene|10A53E2465B5EAA307A099052FBBDF3B62857291|SR4]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|22229825], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • additional information

  • half-life of the RNA: 3 min [pubmed|22229825]
  • maturation of the RNA requires [protein|64C6D783FF3F41C81B216F798A1DC8071345B1ED|PnpA] [pubmed|22229825]
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    labs

  • [SW|Sabine Brantl], Jena, Germany
  • References

    Reviews

  • 31075979
  • Research papers

  • 18948176,20525796,23969414,22229825,26234942