D,L-endopeptidase, peptidoglycan hydrolase for cell separation
product
D,L-endopeptidase, peptidoglycan hydrolase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.1|Autolysis][category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.4|Endopeptidases][SW|Categories] containing this gene/protein
[SW|cell wall degradation/ turnover], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|Abh regulon], [SW|AbrB regulon], [SW|CcpA regulon], [SW|SigD regulon], [SW|SigH regulon]Gene
Coordinates on the chromosome (coding sequence)
2,115,425 -> 2,116,669
The protein
Catalyzed reaction/ biological activity
cleaves the peptide bond between D-Glu (position 2 in the peptioglycan peptide) and m-diamino pimelic acid (position 3) [Pubmed|18266855]Protein family
Cu-Zn superoxide dismutase family (according to Swiss-Prot)Paralogous protein(s)
the C-terminal D,L-endopeptidase domains of [protein|search|LytE], [protein|search|LytF], [protein|search|CwlS], and [protein|search|CwlO] exhibit strong sequence similarity[SW|Domains]
contains four N-acetylglucosamine-polymer-binding [SW|LysM domain]s [Pubmed|24355088,18430080]C-terminal D,L-endopeptidase domain [Pubmed|22139507][SW|Localization]
cell membrane (according to Swiss-Prot)localizes to cell septa and poles [Pubmed|22139507]Expression and Regulation
[SW|Sigma factor]
[protein|search|SigD], [protein|search|SigH], according to [Pubmed|22139507]Regulation
repressed by glucose (3-fold) ([protein|search|CcpA]) [Pubmed|12850135]Regulatory mechanism
[protein|search|CcpA]: transcription repression[protein|search|Abh] and [protein|search|AbrB]: synergistic transcription repression [Pubmed|20817675]References
Reviews
Original publications
16855244,12850135,22139507,20817675,24355088 
