chaperonin, universally conserved protein
function
protein folding and re-folding
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.2|Chaperones/ protein folding][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins][SW|Categories] containing this gene/protein
[SW|chaperones/ protein folding], [SW|heat shock proteins], [SW|essential genes], [SW|universally conserved proteins], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|HrcA regulon]Gene
Coordinates on the chromosome (coding sequence)
649,903 -> 650,187
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Protein family
groES chaperonin family (according to Swiss-Prot)Modification
phosphorylated on Ser-36 [Pubmed|20509597]Structure
[PDB|1WE3] ([SW|GroEL]-[SW|GroES] complex from ''Thermus thermophilus'', 65% identity) [Pubmed|15296740][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[SW|GroEL]-[SW|GroES]Additional information
[SW|universally conserved protein]Expression and Regulation
Operon
''[SW|groES]-[SW|groEL]'' [Pubmed|1350777][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1350776]Regulation
induced by heat shock ([protein|search|HrcA]) [Pubmed|1350777,8576042]Regulatory mechanism
[protein|search|HrcA]: transcription repression [Pubmed|8576042]Additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]Labs working on this gene/protein
[SW|Wolfgang Schumann], Bayreuth University, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/schumann_research.htm Homepage]References
1350777,1350776,8576042,7592421,20509597,15378759,15296740 
