SubtiBank SubtiBank
groES
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groES

chaperonin, universally conserved protein
locus
BSU06020
pI
4.59
mw
10.04 kDa
protein length
gene length
282 bp Sequence Blast
function
protein folding and re-folding
product
chaperonin
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.2|Chaperones/ protein folding]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]
  • Gene

    Coordinates
    649,903 → 650,187

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Protein family

  • groES chaperonin family (according to Swiss-Prot)
  • Modification

  • phosphorylated on Ser-36 [Pubmed|20509597]
  • Structure

  • [PDB|1WE3] ([protein|8F3DEE8828CA6BAAAF6DB2DA4349EF7AA9DF89F8|GroEL]-[protein|0D8B3F1F86FDBAE0F3B3651F456340F147B394AF|GroES] complex from ''Thermus thermophilus'', 65% identity) [Pubmed|15296740]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Additional information

  • [SW|universally conserved protein]
  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
  • Expression and Regulation

    Operons

    genes
    [gene|0D8B3F1F86FDBAE0F3B3651F456340F147B394AF|groES]-[gene|8F3DEE8828CA6BAAAF6DB2DA4349EF7AA9DF89F8|groEL]
    description
    [Pubmed|1350777]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1350776], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|2E57DFB4162EF0CE759C1FC42C637E1B9E4B2F7E|HrcA]: repression, [Pubmed|8576042], in [regulon|2E57DFB4162EF0CE759C1FC42C637E1B9E4B2F7E|HrcA regulon]
  • regulation

  • induced by heat shock ([protein|search|HrcA]) [Pubmed|1350777,8576042]
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    Labs working on this gene/protein

  • [SW|Wolfgang Schumann], Bayreuth University, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/schumann_research.htm Homepage]
  • References

    Reviews

  • 28271487
  • Original publications

  • 1350777,1350776,8576042,7592421,20509597,15378759,15296740,27184767