SubtiBank SubtiBank
groES
An ordered knock out library of all non-essential genes in B. subtilis is now available at Addgene. Information on ordering a copy can be found here. See Koo et al. 2017 for details about library construction.

groES

chaperonin, universally conserved protein
locus
BSU06020
pI
4.59
mw
10.04 kDa
protein length
gene length
282 bp Sequence Blast
function
protein folding and re-folding
product
chaperonin
essential
yes
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.2|Chaperones/ protein folding]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]
  • Gene

    Coordinates
    649,903 → 650,187

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Protein family

  • groES chaperonin family (according to Swiss-Prot)
  • Modification

  • phosphorylated on Ser-36 [Pubmed|20509597]
  • Structure

  • [PDB|1WE3] ([protein|8F3DEE8828CA6BAAAF6DB2DA4349EF7AA9DF89F8|GroEL]-[protein|0D8B3F1F86FDBAE0F3B3651F456340F147B394AF|GroES] complex from ''Thermus thermophilus'', 65% identity) [Pubmed|15296740]
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Additional information

  • [SW|universally conserved protein]
  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
  • Expression and Regulation

    Operons

    genes
    [gene|0D8B3F1F86FDBAE0F3B3651F456340F147B394AF|groES]-[gene|8F3DEE8828CA6BAAAF6DB2DA4349EF7AA9DF89F8|groEL]
    description
    [Pubmed|1350777]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1350776], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • regulatory mechanism

  • [protein|2E57DFB4162EF0CE759C1FC42C637E1B9E4B2F7E|HrcA]: repression, [Pubmed|8576042], in [regulon|2E57DFB4162EF0CE759C1FC42C637E1B9E4B2F7E|HrcA regulon]
  • regulation

  • induced by heat shock ([protein|search|HrcA]) [Pubmed|1350777,8576042]
  • view in new tab

    Labs working on this gene/protein

  • [SW|Wolfgang Schumann], Bayreuth University, Germany [http://www.genetik.uni-bayreuth.de/LSGenetik1/schumann_research.htm Homepage]
  • References

    Reviews

  • 28271487
  • Original publications

  • 1350777,1350776,8576042,7592421,20509597,15378759,15296740,27184767