SubtiBank SubtiBank
trpS
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trpS

tryptophanyl-tRNA synthetase
locus
BSU11420
pI
6.54
mw
37.04 kDa
protein length
330 aa Sequence Blast
gene length
990 bp Sequence Blast
function
translation
product
tryptophanyl-tRNA synthetase
essential
yes
ec
6.1.1.2
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    1,218,113 → 1,219,105

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • ATP L-tryptophan tRNA(Trp) = AMP diphosphate L-tryptophyl-tRNA(Trp) (according to Swiss-Prot)
  • Protein family

  • class-I aminoacyl-tRNA synthetase family (according to Swiss-Prot)
  • Structure

  • [PDB|3PRH] (Val144Pro mutant) [Pubmed|21224416]
  • [PDB|1BM2] (complex with tryptophan, ''Geobacillus stearothermophilus'')
  • [PDB|1MAW] (complex with ATP, ''Geobacillus stearothermophilus'')
  • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    genes
    [gene|0D6CB84E74C32B0384BDC7740AA317EDEC5D60B6|trpS]
    description
    [Pubmed|8915527]

    regulation

  • induced by tryptophan limitation ([protein|search|T-box]) [Pubmed|8915527]
  • additional information

  • A [SW|ncRNA] is predicted between [gene|0D6CB84E74C32B0384BDC7740AA317EDEC5D60B6|trpS] and [gene|302DFA46D73E18C4663468ED6033C55056744475|oppA] [PubMed|20525796]
  • the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
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    References

    Reviews

  • 11163353
  • Original publications

  • 19258532,8932308,8915527,21224416,20525796,26555258,27812824,29794222