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dhbC [Sat May 21 2016 12:50:29 GMT+0200 (CEST)]
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dhbC [Sat May 21 2016 12:50:29 GMT+0200 (CEST)]

isochorismate synthase
locus
BSU31990
pI
5.00
mw
43.00 kDa
function
biosynthesis of the siderophore bacillibactin
product
isochorismate synthase
essential
no
ec
5.4.4.2
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
  • [SW|Categories] containing this gene/protein

  • [SW|acquisition of iron], [SW|iron metabolism], [SW|phosphoproteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|Fur regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,290,289 -> 3,291,485

    The protein

    Catalyzed reaction/ biological activity

  • Chorismate = isochorismate (according to Swiss-Prot)
  • Protein family

  • isochorismate synthase family (according to Swiss-Prot)
  • Modification

  • phosphorylation on Ser-271 [Pubmed|17218307]
  • Structure

  • [PDB|3OS6], (from ''B. anthracis'', 56% identity, 70% similarity)
  • Expression and Regulation

    Operon

  • ''[protein|search|dhbA]-[protein|search|dhbC]-[protein|search|dhbE]-[protein|search|dhbB]-[protein|search|dhbF]'' [Pubmed|8921902]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|8550523]
  • Regulation

  • induced by iron starvation ([protein|search|Fur]) [Pubmed|12354229]
  • Regulatory mechanism

  • [protein|search|Fur]: transcription repression [Pubmed|12354229]
  • [protein|search|AbrB]: transcription repression [Pubmed|20817675]
  • Additional information

  • the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] [PubMed|21815947]
  • the ''[protein|search|dhbA]-[protein|search|dhbC]-[protein|search|dhbE]-[protein|search|dhbB]-[protein|search|dhbF]'' operon is strongly unregulated in a ''[SW|kre]'' mutant [Pubmed|26110430]
  • References

  • 8224884,11112781,11790741,12354229,17218307,8921902,8550523,20817675,21815947,26110430