murD

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase

Locus: BSU_15200

Isoelectric point: 5.57

Molecular weight: 49.49 kDa

Protein length: 451 aa

Gene length: 1356 bp

Function: peptidoglycan precursor biosynthesis

Product: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase

Essential: yes

E.C.: 6.3.2.9

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
• Groups of genes → Essential genes

Gene

Coordinates: 1,588,901 1,590,256

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + D-glutamate + UDP-N-acetyl-α-D-muramoyl-L-alanine --> ADP + H⁺ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate (according to UniProt)

Protein family

• MurCDEF family (according to UniProt)

Structure

• 3LK7 (from Streptococcus agalactiae, 50% identity)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: murE-mraY-murD-spoVE-murG-murB-divIB-ylxW-ylxX-sbp
  Description: PubMed

  Sigma factors

  • SigE: sigma factor, PubMed, in SigE regulon

  Regulatory mechanism

  • stringent response: negative regulation, in stringent response
  • SpoIIID: repression, PubMed, in SpoIIID regulon

  Regulation

  • expressed during vegatative growth PubMed

References

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