general stress protein, degradation of damaged thiol-containing proteins, glyoxalase III-like enzyme
function
detoxification of methylglyoxal
product
glyoxalase III-like enzyme
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.4|Additional proteins involved in proteolysis][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][SW|Categories] containing this gene/protein
[SW|proteolysis], [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress]This gene is a member of the following [SW|regulons]
[SW|AdhR regulon], [SW|SigB regulon], [SW|SigM regulon]Gene
Coordinates on the chromosome (coding sequence)
2,757,492 -> 2,758,001
The protein
Catalyzed reaction/ biological activity
methylglyoxal --> D-lactate [Pubmed|24330391]Protein family
peptidase C56 family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YfkM]Expression and Regulation
Operon
''[protein|search|adhA]-[protein|search|yraA]'' [Pubmed|19170879]''[protein|search|yraA][SW|Sigma factor]
''[protein|search|yraA]'': [protein|search|SigB] [Pubmed|15805528], [protein|search|SigM] [Pubmed|17434969]Regulation
''[protein|search|adhA]'': induced in the presence of the toxic carbonyls methylglyoxal and formaldehyde ([protein|search|AdhR]) [Pubmed|19170879]''[protein|search|yraA]'': induced by stress ([protein|search|SigB]) [Pubmed|15805528]Regulatory mechanism
[protein|search|AdhR]: transcription activation [Pubmed|19170879]References
17434969,19170879,22582280,15805528,17434969,24330391 
