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bceS [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
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bceS [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

two-component sensor kinase, regulation of bceA-bceB in response to bacitracin, plectasin, mersacidin and actagardine
locus
BSU30390
pI
5.00
mw
38.00 kDa
function
resistance against toxic peptides
product
two-component sensor kinase (OmpR family)
essential
no
synonyms
ytsB

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]
  • [SW|Categories] containing this gene/protein

  • [SW|protein modification], [SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins], [SW|phosphoproteins]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,112,190 -> 3,113,194

    The protein

    Catalyzed reaction/ biological activity

  • autophosphorylation, phosphorylation of [protein|search|BceR]
  • [SW|Domains]

  • two transmembrane segments, C-terminal histidine phosphotransferase domain
  • Modification

  • autophosphorylation on a His residue
  • Effectors of protein activity

  • binding of [protein|search|BceB] in the absence of bacitracin inhibits [protein|search|BceS] autophosphorylation [Pubmed|25118291]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • [SW|Interactions]

  • [protein|search|BceS]-[protein|search|BceR] [Pubmed|25118291]
  • [protein|search|BceB]-[protein|search|BceS], in the absence of bacitracin [Pubmed|25118291,23687272,21283517]
  • Expression and Regulation

    Operon

  • ''[protein|search|bceR]-[protein|search|bceS]'' [Pubmed|12399481]
  • Biological materials

    Mutant

  • MGNA-A166 (ytsB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/166 NBRP B. subtilis, Japan]
  • References

    Reviews

  • 27344142
  • Original publications

  • 10094672,18394148,12890034,14651641,21283517,20606066,22964256,21078927,17905982,23687272,25118291,26199330