SubtiBank SubtiBank
ispH [Mon Oct 31 2016 10:57:23 GMT+0100 (CET)]
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ispH [Mon Oct 31 2016 10:57:23 GMT+0100 (CET)]

(E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase, 7th step in the MEP pathway of isoprenoid biosynthesis
locus
BSU25160
pI
5.00
mw
34.00 kDa
function
MEP pathway of isoprenoid biosynthesis
product
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase
essential
yes
ec
1.17.1.2
synonyms
yqfP

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of lipids], [SW|essential genes]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,596,535 -> 2,597,479

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Isopentenyl diphosphate NAD(P) H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate NAD(P)H (according to Swiss-Prot)
  • Protein family

  • ispH family (according to Swiss-Prot)
  • [SW|Cofactors]

  • [3 Fe- 4 S] cluster
  • Structure

  • [PDB|3F7T] (IspH from ''E. coli'', 38% identity) [Pubmed|19569147]
  • References

  • 17458547,19569147,23840410