SubtiBank SubtiBank
ispH [2019-07-05 10:57:50]
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ispH [2019-07-05 10:57:50]

(E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase, 7th step in the MEP pathway of isoprenoid biosynthesis
locus
BSU25160
pI
5.61
mw
34.77 kDa
protein length
314 aa Sequence Blast
gene length
945 bp Sequence Blast
function
MEP pathway of isoprenoid biosynthesis
product
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase
essential
yes
ec
1.17.1.2
synonyms
yqfP

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • Gene

    Coordinates
    2,596,535 2,597,479

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Catalyzed reaction/ biological activity

  • Isopentenyl diphosphate NAD(P) H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate NAD(P)H (according to Swiss-Prot)
  • Protein family

  • ispH family (according to Swiss-Prot)
  • [SW|Cofactors]

  • Fe-S cluster [pubmed|29292548]
  • Structure

  • [PDB|3F7T] (IspH from ''E. coli'', 38% identity) [Pubmed|19569147]
  • Expression and Regulation

    Operons

    genes
    [gene|9B1EA9872500280D6360EECD3D7344A1974910CA|yqfQ]-[gene|08F1D9AD2D51D8513AFFA57E8ED69DB8EF97AD88|ispH]
    description
    [Pubmed|22383849]
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    genes
    [gene|08F1D9AD2D51D8513AFFA57E8ED69DB8EF97AD88|ispH]
    description
    [Pubmed|22383849]
    view in new tab

    References

  • 17458547,19569147,23840410,27791134