The second international online conference
#Subtillery2021 will be held 14th - 18th June - save the date, for more information see the
conference website!
The 21st
International Conference on Bacilli has been postponed to 2022 and will take place in Prague.
speA
arginine decarboxylase, required for [SW|biofilm formation]
function
spermidine, polyamine biosynthesis
product
arginine decarboxylase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.6|Metabolism of polyamines][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation]Gene
Coordinates
1,534,279 → 1,535,751
Phenotypes of a mutant
no [SW|biofilm formation] [Pubmed|24529384,20876533]The protein
Catalyzed reaction/ biological activity
H+ + L-arginine --> agmatine + CO2 (according to UniProt)Protein family
Orn/Lys/Arg decarboxylase class-I family (together with [protein|EEF3E572ED2F23581EB9B48D16B3112B886F7975|YaaO]) (according to UniProt)Paralogous protein(s)
[protein|EEF3E572ED2F23581EB9B48D16B3112B886F7975|YaaO] [SW|Cofactors]
PLP (according to UniProt)Structure
[PDB|2X3L] (from Staphylococcus aureus, 28% identity) [pubmed|20419351][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]
description
[pubmed|22383849]
view in new tabBiological materials
Mutant
CS210 (''[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]''::''aphA3'', available in [SW|Colin Harwood]'s and [SW|Jörg Stülke]'s labs) [Pubmed|27197833]BKE14630 (Δ[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATTGTTTTCCCACCTTTG, downstream forward: _UP4_TAAAAAATAAAAAGCATGCGBKK14630 (Δ[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATTGTTTTCCCACCTTTG, downstream forward: _UP4_TAAAAAATAAAAAGCATGCGReferences
24529384,19255484,9723923,20876533,27197833,20419351