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sweC
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sweC

cofactor of the [protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|FtsE]-[protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|FtsX] complex
locus
BSU_24940
pI
9.01
mw
16.88 kDa
protein length
154 aa Sequence Blast
gene length
465 bp Sequence Blast
function
control of [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|CwlO] activity in peptidoglycan elongation
product
cofactor of the [protein|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|FtsE]-[protein|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|FtsX] complex
essential
no
synonyms
yqzC
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    2,576,717 2,577,181

    Phenotypes of a mutant

  • synthetic lethal with [protein|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|LytE], this can be suppressed by point mutations in [gene|8BF7EB539B53D75BD30BD30ABF27106D6A0B030B|ftsE] or [gene|E22D0F0AC56DC95AFC02E7F55FCD5FAA44B6B490|ftsX] [pubmed|31437162]
  • cells are shorter and fatter than wild-type, cells are bent and curved, both phenotypes depend on the presence of [protein|4F9D70C4BB4FCA809BEAC341C3F8122FB7FD8872|CwlO] [pubmed|31437162]

    • The protein

    [SW|Localization]

  • cell membrane (integral), C-terminal cytoplasmic domain [pubmed|31437162]

    • Expression and Regulation

    Operons

    genes
    [gene|5F184E491602D548AAE8E6D598BB742513770F73|sweD]-[gene|0BC657B63EE124B17FDA7914262E706B2CC9ABC1|sweC]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A]: repression, [Pubmed|14651647], in [regulon|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A regulon]

    • regulation

  • repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]
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    Biological materials

    Mutant

  • MGNA-C484 (yqzC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2482 NBRP B. subtilis, Japan]
  • BKE24940 ([gene|0BC657B63EE124B17FDA7914262E706B2CC9ABC1|sweC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE24940 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAATGCCTGAATGCCCCGTT, downstream forward: _UP4_TAAAAAAACAGGCTGACTCA
  • BKK24940 ([gene|0BC657B63EE124B17FDA7914262E706B2CC9ABC1|sweC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK24940 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAATGCCTGAATGCCCCGTT, downstream forward: _UP4_TAAAAAAACAGGCTGACTCA

    • References

  • 14651647,31437162