SubtiBank SubtiBank
valS
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valS

valyl-tRNA synthetase
Locus
BSU_28090
Isoelectric point
4.87
Molecular weight
101.55 kDa
Protein length
880 aa Sequence Blast
Gene length
2643 bp Sequence Blast
Function
translation
Product
valyl-tRNA synthetase
Essential
yes
E.C.
6.1.1.9
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Protein synthesis, modification and degradation → Translation → Aminoacyl-tRNA synthetases
  • Groups of genes → Essential genes
  • Groups of genes → Efp-dependent proteins

    • Gene

    Coordinates
    2,866,664 2,869,306

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + L-valine + tRNA(Val) --> AMP + diphosphate + L-valyl-tRNA(Val) (according to UniProt)

    • Protein family

  • Class-I aminoacyl-tRNA synthetase family (according to UniProt)

    • Structure

  • 1IYW (from Thermus thermophilus, 41% identity, 60% similarity) PubMed

    • Additional information

  • belongs to the 100 most abundant proteins PubMed

    • Expression and Regulation

    Operons

    Genes
    valS-folC
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • T-box: transcription termination/antitermination, via riboswitch, in T-box

    • Regulation

  • induced by valine limitation (T-box) PubMed
  • the T-box RNA is degraded by RNase Y PubMed
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    Additional information

  • translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

    • References

    Reviews

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    Original Publications

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