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tlpB
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tlpB

membrane-bound chemotaxis receptor, methyl-accepting chemotaxis protein, acts also as pH sensor, responds to increasing pH as an attractant signal
Locus
BSU_31230
Isoelectric point
4.73
Molecular weight
71.36 kDa
Protein length
662 aa Sequence Blast
Gene length
1989 bp Sequence Blast
Function
control of chemotaxis, sensing of alkaline environments
Product
methyl-accepting chemotaxis protein
Essential
no
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
3,204,067 3,206,055

The protein

Paralogous protein(s)

Domains

  • Cache domain (aa 153-228) (according to UniProt)
  • HAMP domain (aa 203-355) (according to UniProt)
  • Methyl-accepting transducer domain (aa 374-610) (according to UniProt)
  • Structure

  • 6S1K (from E. coli, corresponds to aa 285 ... 616, 29% identity) PubMed
  • Localization

  • cell membrane PubMed
  • Expression and Regulation

    Operons

    Genes
    Description

    Sigma factors

  • SigD: sigma factor, PubMed, in SigD regulon
  • Additional information

  • in minimal medium, TlpB is present with 2,500 +/- 740 molecules per cell PubMed
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    Biological materials

    Mutant

  • BKE31230 (tlpB::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTCTCGTTGACTCCTCCT, downstream forward: _UP4_TAATGAAACGAGAAAGCGGC
  • BKK31230 (tlpB::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTCTCGTTGACTCCTCCT, downstream forward: _UP4_TAATGAAACGAGAAAGCGGC
  • References

    Reviews

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    Original publications

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