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spoIIT

co-activator (with SpoIIR) for triggering SpoIIGA-dependent processing of SigE

Locus

BSU_36770

Isoelectric point

6.88

Molecular weight

28.48 kDa

Protein length

246 aa Sequence Blast

Gene length

741 bp Sequence Blast

Function

control of SigE processing and activation

Product

co-activator (with SpoIIR) for triggering SpoIIGA-dependent processing of SigE

Essential

Synonyms

ywmB

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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Categories containing this gene/protein

Lifestyles → Sporulation → Sporulation/ other

Gene

Coordinates

3,779,293 3,780,033

Phenotypes of a mutant

mild sporulation defect due to inefficient activation of SigE PubMed

inactivation of spoIIT reduces sporulation efficiency to 38% that of wild type cells; abortively disporic PubMed

The protein

Structure

2FPN

Localization

secreted from the forespore to the intermembrane space between the forespore and the mother cell PubMed

Expression and Regulation

Operons

Genes

ywzB-spoIIT-murAA

Description

PubMed

Sigma factors

SigA: sigma factor, PubMed, in SigA regulon

SigF: sigma factor, PubMed, in SigF regulon

Regulation

expressed early during sporulation in the forespore (SigF) PubMed

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Genes

spoIIT-murAA

Description

PubMed

Regulation

expressed early during sporulation in the forespore (SigF) PubMed

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Biological materials

Mutant

MGNA-A189 (ywmB::erm), available at the NBRP B. subtilis, Japan

BKE36770 (spoIIT::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTCATCTCTCCCCCTT, downstream forward: _UP4_TAATATAGAGAATTTAGGGA

BKK36770 (spoIIT::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTCATCTCTCCCCCTT, downstream forward: _UP4_TAATATAGAGAATTTAGGGA

References

Reviews

Original Publications